|Cell Fusion System|
The Hybrimune electrofusion system is an advanced cell fusion system capable of delivering variable ac pulse frequencies. Oﬀering optimized and reproducible protocols, the system uses patented technology to enhance the alignment of cells in large volumes; as many as 9 million cells can be fused in one run. With it, researchers producing monoclonal antibodies can achieve high levels of eﬃciency with large-volume throughput; up to 180 million cells can be fused in a matter of milliseconds. This yield of antigen-speciﬁc clones compares very favorably with that of the polyethylene glycol–
mediated process. Chambers with 2- and 9-ml capacities allow scalable throughputs. Electrofusion generates hybridoma lines secreting monoclonal antibodies with high binding speciﬁcity and biological activity.